An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions

Optogenetic perturbation and bioluminescence imaging to analyze cell-to-cell transfer of oscillatory information.

Cells communicate with each other to coordinate their gene activities at the population level through signaling pathways. It has been shown that many gene activities are oscillatory and that the frequency and phase of oscillatory gene expression encode various types of information. However, whether or how such oscillatory information is transmitted from cell to cell remains unknown. Here, we de...

An algorithm to analyze stability of gene-expression patterns

Many problems in the field of computational biology consist of the analysis of so-called gene-expression data. The successful application of approximation and optimization techniques, dynamical systems, algorithms and the utilization of the underlying combinatorial structures lead to a better understanding in that field. For the concrete example of gene-expression data we extend an algorithm, w...

An Optogenetic Method to Modulate Cell Contractility during Tissue Morphogenesis

Morphogenesis of multicellular organisms is driven by localized cell shape changes. How, and to what extent, changes in behavior in single cells or groups of cells influence neighboring cells and large-scale tissue remodeling remains an open question. Indeed, our understanding of multicellular dynamics is limited by the lack of methods allowing the modulation of cell behavior with high spatiote...

Effect of Exposure to Quran Recitation on Cell Viability, Cell Migration, and BCL2L12 Gene Expression of Human Prostate Adenocarcinoma Cell Line in Culture

Background and Objectives: Prostate cancer is the third most important cause of cancer deaths and one of the most common cancers in the world. Given the limited knowledge on environmental sounds and their effects, the important role of sounds is neglected in every culture across the world. The aim of this study was to investigate the impact of Quran recitation on prostate cancer cell line (PC-3...

Patterns of Gelatinase-B Expression in Leukemic Cell Lines